Objective.We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein\r\n(CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease. Methods.We studied 402 individuals and classified\r\nthem into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, SouthwesternMexico. Blood levels of\r\nCRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score\r\nfor coronary heart disease was determined by the Framinghamâ��s methodology. Results. The TT genotype of SNP rs1130864 was\r\nassociated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated\r\nwith increased levels of CRP (�Ÿ = 0.3; 95%CI: 0.1, 0.5; P = 0.005) and haplotype 7 (TGGG) with higher body mass index (BMI)\r\n(�Ÿ = 0.2; 95%CI: 0.1, 0.3; P < 0.001). The risk score for coronary heart disease was associated with increased levels of CRP, but\r\nnot with any polymorphism or haplotype. Conclusions. The association between the TT genotype of SNP rs1130864 with obesity\r\nand the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the\r\npopulation of Southwestern Mexico.
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